Scientific Name: Manis javanica
Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Deuterostomia-> Chordata-> Craniata-> Vertebrata-> Gnathostomata-> Teleostomi-> Euteleostomi-> Sarcopterygii-> Dipnotetrapodomorpha-> Tetrapoda-> Amniota-> Mammalia-> Theria-> Eutheria-> Boreoeutheria-> Laurasiatheria-> Pholidota-> Manidae-> Manis
Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008] [NCBI] [Proteinatlas]
Data set information
| Project | Date | Technology | Tissue | Condition | Cell | PMID/DOI |
|---|---|---|---|---|---|---|
| Vthunter_0035 | 2021.04 | 10X Genomics | Duodenum | Normal | 1482 | Link |
| Vthunter_0036 | 2021.04 | 10X Genomics | Esophagus | Normal | 24581 | Link |
| Vthunter_0037 | 2021.04 | 10X Genomics | Heart | Normal | 12958 | Link |
| Vthunter_0038 | 2021.04 | 10X Genomics | Kidney | Normal | 4481 | Link |
| Vthunter_0039 | 2021.04 | 10X Genomics | LargeIntestine | Normal | 3328 | Link |
| Vthunter_0040 | 2021.04 | 10X Genomics | Liver | Normal | 5694 | Link |
| Vthunter_0041 | 2021.04 | 10X Genomics | Lung | Normal | 13720 | Link |
| Vthunter_0042 | 2021.04 | 10X Genomics | Spleen | Normal | 3207 | Link |
| Vthunter_0043 | 2021.04 | 10X Genomics | Stomach | Normal | 12485 | Link |
Featureplot of receptors
Expression: Broad expression in fat (RPKM 2.7), lymph node (RPKM 1.6) and 14 other tissues?
